August 15, 2021 10 min read

UV Sanitizer:

an advanced, ubiquitous, and reliable portable disinfection machine that kills 99.99% of germs, including the SARS-CoV2 coronavirus

Leveraging the UVC irradiation in the global fight against infectious and zoonotic diseases including COVID-19

UV light is electromagnetic radiation with a wavelength range of 100–400 nm shorter than the visible light wavelength (400–700 nm) but longer than the wavelength of x-rays (100 nm). Based on wavelength, UV light is further categorized into four distinct spectra named vacuum UV, UVC, UVB, and UVA, with their wavelength range from 100–200 nm, 200–280 nm, 280–315 nm, and 315–400 nm, respectively.

Among all these, the UVC spectrum is considered to be a potent germicidal. Despite knowing the germicidal ability of UVC light, its use as disinfection and infectious diseases prevention is still in the early phase (Vázquez and Hanslmeier 2005; Dai et al., 2012). far ultraviolet working principle

UVC is a ubiquitous, cost-effective, reliable, and powerful disinfectant tool against microorganisms, including viruses, harmful bacteria, protozoa, mold, and spores.

Specifically, the UCV range, which covers wavelengths between 200 nm and 280 nm, is capable of eliminating pathogenic microbes, including the SARS-COV2 (the causative agent of the COVID-19 pandemic).

 How UVC kills pathogenic microbes: 

During the disinfection process, the UVC light targets the DNA of the microbe. The UVC light, particularly 250-270 nm wavelength, is readily absorbed by the microbial nucleic acids and is considered the lethal wavelength for microbes.

The UVC wavelength of 253.7 nm is termed as the germicidal spectrum as it is the most lethal wavelength for microbial inactivation. Exposure of microbes to UVC light results in pyrimidine dimers in the structure of microbial DNA and RNA (Fig. 1). The dimerization of thymine (present in DNA) results in the development of cyclobutane dimers. As more thymine dimers are formed, damage starts accumulating inside the DNA.

uv light make bacteria germ dna-explosion

The formation of dimers results in bumps inside DNA. These cellular mutations inside microbes negatively affect the growth and risk of non-repairable damage in DNA. Eventually, the extensive damage in DNA results in microbial death. DNA replication stops, which reduce the division of microbes.

Even if the microbe replicates, it will lead to defective replication, which ultimately inhibits microbial viability, thus limiting the spread of microbes from the surfaces (Dai et al., 2012).

bio grade change ultraviolet made

Fig. 1 UVC light results in defects inside the DNA of microbes (retrieved from http://microbiologyon-line.blogspot.com/2009/09/radiation-sterilization-method.html) on December 15, 2020

Pathogens provoking most death worldwide and the role of UVC irradiation:

Every year pathogenic microbes including viruses, bacteria, and fungi are associated with millions of hospitalization and deaths across the globe.

Therefore, the knowledge of the most prevalent and infectious diseases is essential for planning disease prevention measures in terms of public health safety.

Not all but at least precise and critical information regarding the crucial pathogenic and zoonotic microbes is the need of time for developing the disease prevention strategies such as disinfection and vaccination.

ultraviolet disifnector protect doctor and nurse from pandemic

According to the 2017 report published in Bioscience Biotechnology Research Communications journal, major pathogens are responsible for 8.8 million casualties worldwide, with Streptococcus pneumonia (causative agent of pneumococcal pneumonia) is at the top of the list causing 1.6 million deaths annually.

Subsequent deadly pathogens in this list are the Human immunodeficiency virus (1.2 million deaths), Mycobacterium tuberculosis (1.1 million deaths), and Plasmodium falciparum (0.7 million deaths).

far ultraviolet destroy covid19 virus

According to the 2019 AR threat report, approximately 2.8 million antibiotic resistance infections occur every year in the United States alone, causing 35000 deaths (CDC, 2019).

Similarly, a previous report from the European Antimicrobial Resistance Surveillance Network has claimed that an estimated number of people who died directly as a result of antimicrobial-resistant bacteria has reached 33000 per anum and is continuously exceeding.

Such a considerable disease burden is comparable to other infectious diseases such as tuberculosis, influenza, and HIV/AIDs combined, and that 75% of this burden comes from healthcare-associated infections.

This disease burden can be lowered through adequate sanitation and managemental interventions (ECDPC, 2018).

UVC light can be helpful in infection control by limiting microbial dissemination and restricting their transmission. Certain viruses such as coronaviruses and influenza viruses continuously evolve by incorporating mutations inside their genome and thus survive the hostile immune-competent environment of the host (i.e., humans) through evasion of the host immune system.

Therefore, it is challenging to develop a vaccine against these highly mutating viruses as the vaccine developed against a single strain will not provide immunity against the other mutant strain of the same virus.

The benefit of using the UVC light is that it can effectively inactivate these highly mutating viruses.

far ultraviolet destroy DNA chain of virus

Not only UVC works against the common pathogens, but it also can be effective against the bacterial strains which are multidrug-resistant (i.e., Staphylococcus aureus and Enterococcus faecalis) and are not curable with the currently available antibiotics available in the market (Conner-Kerr et al., 1998). U

VC, as a source of disinfection, has limitless potential applications in several fields. Currently, UVC light is being used as a disinfectant on a commercial scale and has domestic, medical, and industrial applications, from water treatment to the curing of inks to hygiene and infection control.

UVC light is commonly used in healthcare settings and hospitals for a cleanroom environment. In combination with indoor air filtration, UVC light can also be implied for the elimination of airborne pathogens.

This protocol could be applied for the management of immunocompromised patients or patients under high risk, thus improving the prognosis of patient's health through maintenance of a healthier and safer environment for patients, visitors, and the staff by controlling the transmission of nosocomial infection.

UVC radiation in the global fight against COVID-19:

Coronavirus (SARS-CoV2) has devastated the global economy and killed more than 274000 people worldwide. As the conversation shifts towards the reopening of the countries and getting people back to work, proper and adequate sanitation in overcrowded and public places would be an essential step towards normalization.

In advanced countries like China and the US, robots, drones are being used to spray chemical disinfectants in public places. Airlines and companies are using fogging as a sanitation technique to keep their facilities clean.

hospital use ultraviolet light for disinfection

UVC light has been tested against a myriad of viruses such as Porcine Parvovirus, Poliovirus, Minute Mouse virus, etc. According to an article published in the Journal of Virological Methods, SARS caused by the coronavirus is eliminated through exposure to UV light in the 253.7 nm range (Darnell et al., 2004).

The high vulnerability of coronaviruses towards UVC light has also been reported by German researchers from the University of Applied Sciences, Ulm.

When it comes to the latest pandemic of COVID-19, UV light has been confirmed to be effective in eliminating the SARS-CoV2. Recent studies provide evidence that UVC light successfully inactivates the SARS-CoV-2 at a shallow dose of 1.2mJ/cm2 and that the SARS-CoV-2 could be inactivated by standard UVC disinfection protocols.

Recently a groundbreaking report from Irving medical Centre New York has suggested the efficient and effective inactivation of airborne human coronaviruses by UV light at a wavelength of 222 nm (Buonanno et al., 2020).

ultraviolet light for disinfection for plublic places

Most importantly, the evidence regarding skin safety at 222nm wavelength has also been established by previous studies. In addition to these, other viruses can also be inactivated efficiently by UVC.

However, the pattern of sensitivity of other viruses to UVC light varies. This variation in sensitivity of the virus particle is not correlated with its shape, size, or type of nucleic acid but maybe dependent on the frequency of sequential pyrimidines as the UVC treatment is already proven to be effective against the previous strains of coronaviruses.

Therefore, it makes sense for the UVC light to be used for the eradication of COVID-19 from rooms and surfaces. Unlike the liquid cleaning agents against COVID-19, no contact with the devices or surfaces is required when sanitizing with UVC light.

There is no downtime for the sterilization process as the area, equipment, and other things can be used immediately after the disinfection.

UVC is superior to conventional liquid disinfectants:

  • UV light does not produce harmful products and is non-toxic to the environment in comparison to liquid disinfectants and cleaning agents.
  • UV light is cost-effective, whereas the use of liquid disinfectant, i.e., chlorine, requires extra public and environmental safety measurements, proper transportation, and storage conditions.
  • The risks of illness and death may be reduced due to UV-C light disinfection compared to chemical disinfection because chemicals are harmful to the environment and human beings.
  • The germicidal efficacy of UVC light is much more as compared to the other sanitation procedures such as sterilization, bleaching and washing, and heat treatment.
  • In contrast to chlorine-based disinfectants, which require a longer time to achieve maximum decontamination of the surfaces, UVC light is very rapid and physically inactivates all pathogens within a shorter period (second to few minutes).
  • Unlike the other cleaning agents, a wand of UVC light can be passed over bacteria hoarders such as floors, keyboards, and handrails without any special training in comparison to liquid and steam cleaners.

As UVC light can effectively inactivate the new coronavirus, therefore it could be a potential and attractive alternative to conventional liquid-based chemicals for disinfecting the surfaces, equipment, and air.

Unique kinds of lamps and devices containing UV lamps are used for this purpose. Check out our new and advance UVC sterilization today.

The background for developing our UVC Sterilizer X:

The reason why we developed our portable & foldable UVC Sterilizer is pretty evident and arguable. Since the outbreak of COID-19, everyone has become very precarious about their health than ever before.

In this awful time of the pandemic, almost everyone has become obsessed about keeping their places and homes clean and germ-free. This has led to the burgeoning demand for UV sanitizerglobally.

Currently, there are a lot of UVC-sterilizer products in the international markets that claim the killing of 99.9% of germs, including the SARS-CoV2, merely with a flash scanning of the contaminated surfaces.

Based on our extensive research and comparison with other UVC devices in the market, we concluded that the results of disinfection and sterilization claimed by all these suppliers & brands are entirely uncertain and exaggerate just to sell their products taking advantage of peoples fear of the current coronavirus pandemic.

People pay a handsome amount for such useless devices with no effective and visible outcome. Therefore, we have stepped forward and developed the patent Dosimeter along with our UVC sanitizer for visual confirmation regarding the working efficacy and agility of our product to kill the targeted bacteria or virus.

We believe that our UVC portable sanitizer product is revolutionary rather than evolutionary. Let's take a look at why our UVC portable sterilizer is far more ubiquitous and different from other products market.

Salient features of our UVC Sterilizer X product:

uvc terilizer x deluxe kit

 

  • Durable and reliable: Our UV sanitizer is instant on, efficient, eco-friendly, and possesses long shelf life, and unaffected by temperature and humidity.
  • Flexible positioning options: Both In-box sterilization and scanning, even DIY stuck on any flat & smooth surface vertically or horizontally.
  • Easy handling and safe to use: Our UVC device is entirely safe and easy to carry and housekeep.
  • High-performance efficacy:Increased UVC disinfection and designed to reduce hospital and community-acquired infections with real-time results
  • Fancy and foldable design: Unlike the other products currently available in the market, we provide foldable silicone bracket
  • Dual functionality: Our UVC sterilizer can be used as a box sterilizer and as an individual modular for scanning.
  • Switchable sterilization modes: Both quick (5 mins) and long time (60 mins) sterilization modes are present in our product
  • Effective and visible results: Dosimeter is one of the most significant aspects while purchasing any kind of UVC device. We developed the dosimeter with different dosage levels along with a readable and clear sterilization manual guide book to help people understand whether effective sterilization or disinfection of the target pathogens is taking place or not. Our UVC Dosimeters are based on colorimetric indicators, which give a visible indication of an accumulated UVC dosage.
  • Unlimited usage: Our UVC device is appropriate for the killing of a variety of viruses, bacteria, mold, and fungi in almost every setting and environment, such as laboratories, cosmetics, pharmaceutical industry, food, and beverage industry, hospitals, laboratories, schools, daycare centers, hotels, gyms, production, and transport vehicles.
  • A diverse range of abilities: Our UVC sanitizer product can perform under a diverse range of processes and conditions.
  • Specific & Readable Sterilization Guidebook: Dosimeter & manual book is available to make our product user-friendly.
  • What you get: In addition to UVC sterilizer device, we provide anti-UVC goggles, shockproof modular bag, dustproof storage bag, USB cable, nano sticker, dosimeter Card (Exclusive by us, values by $300 by a business solution provide), and high class packing in a gift box like the design as that of any cell phone or headphone with a good taste.

Conclusion:

We believe that our uv sanitizer for personal using could change how we handle infection control in crowded and public places. Due to higher potential benefits and reliability, we propose that using our UVC sterilizer device as disinfection may result in developing safer and germ-free surroundings for the population even in this global COVID-19 pandemic.

Imagine the prospect of using our UVC technology in schools and homes. Imagine how this product could facilitate the transition from complete lockdown to partial/smart lockdown and, ultimately, the full normalization, reopening of borders, and international traveling.

We want this transition easy and smooth; therefore, we have provided a guidance manual for easy understanding of people regarding its installation and use.

The UVC range we have implemented in our UVC product is the best possible tool in the market to prevent microbial contamination on all types of surfaces, including airborne pathogens and human coronaviruses.

We believe that the salient features of the product will help the people across the globe, not just during the awful COVID-19 pandemic but also as a potential disinfectant tool for controlling infectious pathogens in the future.

In conclusion, our highly ubiquitous, innovative, and user-friendly UVC-device is scientifically proven and robust and can value-add significantly in keeping our environment, places, and surfaces safe, both within the houses and outside of it.

ultraviolet disifnector protect doctor and nurse from pandemic1

References:

Buonanno, M., Welch, D., Shuryak, I., & Brenner, D. J. (2020). Far-UVC light efficiently and safely inactivate airborne human coronaviruses.

Centers for Disease Control and Prevention. (2016). The burden of foodborne illness: findings. Centers for Disease Control and Prevention.

Centers for Disease Control and Prevention. (2019). Biggest Threats and Data 2019 AR Threats Report.

Conner-Kerr, T. A., Sullivan, P. K., Gaillard, J., Franklin, M. E., & Jones, R. M. (1998). The effects of ultraviolet radiation on antibiotic-resistant bacteria in vitro. Ostomy/wound management44(10), 50-56.

Dai, T., Vrahas, M. S., Murray, C. K., & Hamblin, M. R. (2012). Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections?. Expert review of anti-infective therapy10(2), 185-195.

Darnell, M. E., Subbarao, K., Feinstone, S. M., & Taylor, D. R. (2004). Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV. Journal of virological methods121(1), 85-91.

European Centre for Disease Prevention and Control (ECDPC), November 2018.

Hessling, M., Feiertag, J., & Hoenes, K. (2017). Pathogens provoking most deaths worldwide. Biosci. Biotechnol. Res. Commun10, 1-7.

Kate Bergman, Inactivation of Viruses by UVC Treatment. Eurofins. Lancaster laboratories. Available at https://www.eurofinsus.com/media/447597/uvc_biopharm-dev-week-2014.pdf.

Vázquez, M., & Hanslmeier, A. (2005). Ultraviolet radiation in the solar system (Vol. 331). Springer Science & Business Media.

STERILIZER X UVC
STERILIZER X UVC


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